Some regional prescribing information and facts also notes that temazepam might be used for premedication before minor surgical procedure or other relevant processes 12.
Place individual on facet struggling with you with upper leg bent ahead, lubricate rectal applicator idea, Carefully insert syringe tip in rectum and little by little press plunger
Usage of benzodiazepines, including diazepam, equally applied by itself and together with other CNS depressants, could result in probably deadly respiratory melancholy
rifapentine will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
lapatinib will boost the stage or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
The above mentioned information and facts is supplied for typical informational and educational purposes only. Particular person strategies could change and formulary facts changes. Get in touch with the applicable strategy supplier for quite possibly the most present-day information and facts.
four mg/kg/day] or greater on mg/m2 basis) Cleft palate and exencephaly are the most typical and continuously described malformations produced in these species by administration of large, maternally-toxic doses of diazepam throughout organogenesis
diazepam will improve the stage or impact of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
A heightened danger of congenital malformations along with other developmental abnormalities associated with the use of benzodiazepine medications all through pregnancy has actually been suggested. There may also be non-teratogenic dangers associated with the use of benzodiazepines in the course of pregnancy. There are reviews of neonatal flaccidity, respiratory and feeding complications, and hypothermia in little ones born to moms who have been receiving benzodiazepines late in pregnancy.
sage decreases outcomes of diazepam by pharmacodynamic antagonism. Insignificant/Importance Unfamiliar. Theoretical interaction; some species of sage may cause convulsions.
Coadministration of encorafenib with delicate CYP3A4 substrates could cause greater toxicity or lowered efficacy of such agents.
Psychiatric and paradoxical reactions are regarded to come about when using benzodiazepines (see ADVERSE REACTIONS). Should this happen, use on the drug must be discontinued. These reactions usually tend to come about in small children and the elderly.
fluvoxamine will improve the amount or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
The period of hypnotic effect plus the profile of unwelcome website adverse consequences could be affected because of the distribution and elimination half-life with the administered temazepam and any active metabolites Which might be fashioned 13. When this sort of 50 %-lives are extended, the drug or its metabolite(s) may perhaps accumulate through periods of nightly administration and be linked to impairments of cognitive and motor effectiveness in the course of waking several hours thirteen.